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To demonstrate specificity of the effect, we sought to rescue the decreased mEPSC frequency by pretreating with pyroglutamate (PGA), the precursor of glutamate that is synthesized downstream of GGT, which is blocked by acivicin (Fig

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Further, on evaluating hepatic antioxidant capacity, it was significantly attenuated in MTX group in comparison with CTRL as demonstrated by the significantly lower hepatic GSH and SOD activity (Figures 3B, C)

exposure to environmental toxins, including mold, cigarette smoke, and alcohol