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Arillotta D, Floresta G, Papanti Pelletier GD, Guirguis A, Corkery JM, Martinotti G, Schifano F
Gentle Patches is not a prescription drug or any other controlled substance
Phase 2 Trial Data, What Researchers Are Working From The pivotal Phase 2 trial (Jastreboff et al., NEJM 2023, NCT04881760) enrolled 338 adults across six cohorts over 48 weeks
Instead, they work alongside nutrition, movement, sleep, behavioral support, and ongoing medical care to improve metabolic health
As reported by the American Journal of Managed Care, the approval of an oral semaglutide formulation marked the beginning of what many are calling the oral GLP-1 era. In December 2025, the FDA approved the Wegovy (semaglutide) tablet as the first once-daily oral GLP-1 receptor agonist indicated for chronic weight management in adults with obesity or overweight
