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Butyrate acts blocks the IL-6/STAT3/IL-17 and TLR2-MyD88-NF-B pathways, and bidirectionally regulates cytokine secretion, Specifically, it upregulates anti-inflammatory factors such as IL-4 and IL-10 and downregulates pro-inflammatory factors such as CRP, IL-8, IL-12, and TNF- (66, 67, 91, 92)

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The final submission will focus on data from two key clinical trials, SURMOUNT-1 and SURMOUNT-2

Methods The sources of reagents are listed in electronic supplementary material (ESM) Table 1

Doi: 20