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Immunogenicity testing follows a tiered approach: ECL or ELISA screening for ADA presence, competitive inhibition confirmatory assay, and cell-based neutralization assay for NAb characterization

[Abstract]2022 Nov 25;12(12):1754

Molecular oxygen is converted into singlet form 1 O 2 via photo-oxygenation as well as enzymatic reactions, mediated by peroxidases like lipoxygenase (LOX), dioxygenase and lactoperoxidase

Each method presents limitations: venous blood testing demands frequent sampling and lacks immediacy, whereas urine tests are heavily influenced by renal function, rendering them unsuitable for severe cases

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