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The success of peptide drugs in rare disease applications has demonstrated the value of orphan drug programs in bringing innovative therapies to patients with limited treatment options

Ototoxicity is defined as an increase in the auditory threshold by at least 20 dB at any one test frequency, or at least 10 dB at any two adjacent frequencies, or loss of response at three consecutive frequencies between the baseline and during follow-up studies

The absence of many reports may reflect limited systematic monitoring rather than an absence of risk

Reduced dead space for reduced Insulin waste

When NO is too high (e.g

Yesbut only when medically necessary and separate