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This implies that the FOXO4-p53 interaction effectively induces cellular senescence

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The following framework reflects how a clinically supervised protocol is structured it is not a prescriptive recommendation and must be individualised by your provider

To determine a causal role between senescent cells and tauopathy, we administered intermittent (once every two weeks) senolytic therapy (D+Q) to tau transgenic mice between the ages of 2023 months old with already present tau pathology, neurodegeneration, inflammation and brain atrophy (35)

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