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A narrative review

Large individual variations in NAPQI IC 50 values were observed (Fig

Hexarelin also triggers dose-dependent increases in: ACTH and cortisol (via hypothalamic cross-activation) Prolactin (highest among all GHRPs) Ghrelin-like downstream signaling What makes Hexarelin unique is its GH pulse amplitude it produces the strongest single-dose GH release recorded among all synthetic GHRPs in clinical studies (Arvat et al., 2001)

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Supplementary Figure S3E), indicating that oxidative stress contributes to the toxicity under conditions of severe overdose (Figure 9)

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