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Encouraging results: Novo Nordisks Wegovy, for example, has shown a 20% reduction in heart attack, stroke, or death from heart disease in recent trials

Some patients experience no noticeable difference, while others show a slightly higher resting pulse

7 This is crucial as psoriasis is associated with an increased risk of cardiovascular events 8 and a patient may be taking medications that are metabolised by CYP/P-glycoprotein mechanisms

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Pentose Phosphate Pathway TABLE 1 Classes of G6PD Enzyme Variants Genetics The gene mutations affecting encoding of G6PD are found on the distal long arm of the X chromosome

Conversely, in the adaptive immune system, lack of succinate appears to be of particularly relevance in breaking tissue tolerance and causing inflammation ( Figure 3 )