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Study: Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study

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This pattern is consistent with weight loss being the primary driver, since 15 mg also produces the largest weight loss

The active ingredient (semaglutide or tirzepatide) is the same, but the formulation may differ slightly from the brand-name version

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With a half-life of approximately 7 days, semaglutide reaches what pharmacologists call "steady-state concentration" after 4 to 5 weeks of consistent weekly dosing