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The main reason is metformin, the first-line medicine for type 2 diabetes, which can reduce how well the gut absorbs vitamin B12 over time

doi: 10.1016/j.neuroscience.2015.05.042

OTS athletes show blunted ACTH/prolactin response to second bout

Finally, GSH appears to bind to arsenic methyltransferase (AS3MT) and to increase its activity