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In addition to Ca 2+ -calmodulin regulation, CaMKK2 is also regulated by phosphorylation of the S3-node, which is a control switch in the N-terminal regulatory sequence of CaMKK2 composed of three tandem serine residues (S3) that are sequentially phosphorylated by cyclin-dependent protein kinase-5 (CDK5) and glycogen synthase kinase-3 (GSK3) [40]

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Insulin resistance and diabetes : Triglycerides and insulin resistance form a vicious cycle

But perhaps of greater importance is glutathione's ability to deal directly with the causes of oxidative stress by detoxifying common toxins like mercury, heavy metals, and other organic pollutants

2015 Feb;76(2):201-14