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The compound has demonstrated generally good tolerability in clinical trials to date, with a safety profile largely consistent with other incretin-based therapies (GLP-1 and GLP-1/GIP agonists) that have become standard treatments for obesity and type 2 diabetes

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The structureactivity relationship studies showed that the hydrophobic group in the 4' position was essential for its inhibitory potency [88]

These shifts would alter the pricing floors by letting higher prices pass the value test

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Additionally, the subcostal scanning approach was used to perform quantitative analysis because of avoiding any bowel or ribs shadowing over the liver