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PMID: 17018654 Raun K, et al

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We next hypothesized that NADP oxidation during hypoxia may be due to NADPH consumption by the anti-oxidant machinery which is not matched by the rate of re-supply due to limitations in flux through central metabolism

The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug-reactive T cells in resolved hypersensitivity cases and drug-nave healthy donors

doi: 10.1016/j.cca.2012.06.022 45 NagyGBarczaMGonchoroffNPhillipsPEPerlA