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Intracellular drug redistribution Tumor cells achieve MDR through the precise regulation of intracellular drug distribution and concentrationa fundamental autonomous defense mechanism

Many authors report this capacity to recognize and transport several types of anti-cancer drugs such as doxorubicin with high affinity (Okabe et al., 2005)

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Preliminary experiments The purposes of the experiments were to determine the optimum pH of the buffer solution for non enzymatic and enzymatic reactions of monobromobimane (MBB) with glutathione (GSH) as well as the quenching effect of the presence of excess MBB in a typical reaction mixture on the fluorescence of the reaction product

There is no reliable data

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