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47 In that study the composition of progenitors and new neurons that exit the cell cycle was not altered by deletion of TrkB

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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Di Zazzo A., Gaudenzi D., Yin J., Coassin M., Fernandes M., Dana R., Bonini S

Accordingly, the therapeutic approach is to lower catalytic iron and interrupt chain propagation by combining chelation (e.g., deferoxamine or deferiprone) with restraint of ferritinophagy (NCOA4) to curb Fe release, managing HO-1 induction so heme breakdown does not overexpand LIP, restoring GPX4 capacity via selenium sufficiency and GSH support and deploying radical-trapping antioxidants (ferrostatin-1, liproxstatin-1) to terminate lipid-radical chains

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