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DUBm mediates deubiquitination of H2B which in turn facilitates the recruitment of Ctk1

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Amyloidogenic proteins then interact with cardiolipin in the outer membrane to induce an apoptotic cascade, resulting in neuronal cell death and, ultimately, neurodegenerative disease

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For others, it doesn't

In humans it is synthesized in the liver, kidney, and brain and actively transported to other areas of the body