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Long-term oral treatment of spontaneously hypertensive rats resulted in a considerable reduction in systolic blood pressure as well as a decrease in serum levels of aldosterone, angiotensin II, and the enzyme angiotensin converting enzyme

R., Cornelli U., Dugall M., et al

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The infiltration of immune cells such as macrophages, neutrophils, mast cells, B cells, T cells, NKT cells within the adipose tissue, coupled with the overproduction of inflammatory mediators and adipokines (e.g., leptin and lipocalin), adipocyte-derived MCP-1 and hypertrophy of visceral adipocytes, leads to hypoxia, autophagy, and apoptosis (130)

Using structural analysis, v6pep (KEQWFGNRWHEGYR) was selected from the human CD44v6 domain that interacts with c-Met and inhibits tumor growth and metastasis in a pancreatic cancer model 112,113

Y., & Li, M