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Analysis of publicly available gene expression datasets GSE3189 and GSE46517 showed lower expression, respectively, of both EPAC2 and TXNIP in melanoma compared to melanocytic nevi [64] and higher TXNIP mRNA expression in nevi and a progressive decrease in TXNIP mRNA levels in primary to metastatic lesions [65]

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Hormone and Metabolic Research, 2023;55(01), 40-50 Chivu AM, Blescu E, Pandia LD, Nedelcu RI, Brnzea A, Turcu G, Antohe M, Ion DA