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This study was a key part of the data the FDA reviewed before approving Zepbound for weight management in late 2023

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3 The study authors state that deficiency of some isoforms of carnitine, especially those esterified with short-chain fatty acids, may play an important role in cardiac involvement in course of IBD and could lead, over time, to dilated cardiomyopathy. Chronic Fatigue Syndrome and L-Carnitine Deficiency Apparently, just taking omega-3 fatty acids can improve the effects of the L-carnitine you already have in your body and when taken with L-carnitine are further enhanced

Diabetes Metab Syndr Obes (2017) 10:20722

The increased odds of achieving glycemic targets and the reduced likelihood of treatment intensification reported here suggest improved durability of semaglutide vs DPP4i and suggest that long-term persistence with semaglutide may help to alleviate treatment complexity associated with polypharmacy and increased medication load and reduce end-organ complications long-term

10.2337/dc12-0709 23 RudolphM