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What does this mean for the drugs efficacy

Mease PJ, Gladman DD, Collier DH, et al

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and 4) diabetic group treated with the GLP-1 analogue liraglutide (Lirag, n = 9)

37-39 Abnormal Gonadotropin and Androgen Secretion and Signaling Excessive secretion of luteinizing hormone (LH), one of the pituitary hormones that stimulates maturation of ovarian follicles, appears to play a role in PCOS

As a consequence, one's kidneys are no longer able to reabsorb as much water as they should be absorbing, therefore creating excessive volumes of urine and the subsequent overall dehydration