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GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide that reactivates miniaturized hair follicles through Wnt/beta-catenin signaling, the master switch for hair cycling (Pickart & Margolina, 2018)

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This molecule, SR12343, significantly reduced the release of SASP factors, senescence, and improved markers of senescence in progeroid and naturally aged mice (89)

Later, as GHK accumulates bound copper 2+, GHK-Cu stimulates stem cell differentiation