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NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% in diet-induced obese mouse models without suppressing food intake, suggesting energy expenditure modulation

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This regulation of hormone levels may have rebalanced the endocrine environment in the body by affecting the hypothalamic-pituitary-ovarian axis [24, 25], which effectively ameliorates the endocrine disorders associated with PCOS