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For HNE induction, the activation of the critical AP-1 binding elements in both human GCL genes can is achieved through the Jun N-terminal kinase (JNK) pathway (Dickinson et al., 2002)

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Clinical trial context: According to the manufacturer, the STEP 1 trial demonstrated 14.9% average body weight loss over 68 weeks among participants who also followed reduced-calorie diets and increased physical activity

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