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A dominant-negative Gs (DNGs) was generated 3 by introducing eight mutations: S54N, G226A, E268A, N271K, K274D, R280K, T284D, and I285T

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The literature search was independently performed by three investigators

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The current review will outline the different gutbrain signaling mechanisms that contribute to metabolic homeostasis, highlighting the recent advances in understanding these complex hormonal and neural pathways