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In the late stages of PD, the key molecular pathogenic mechanisms include the misfolding and aggregation of -synuclein, mitochondrial dysfunction, impaired protein clearance (related to inefficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxidative stress (57)

Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-T2D trial

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Fatigue Fatigue affects a subset of GLP-1 users, typically during the first four to eight weeks of treatment

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Nutrient sensing in the gut and the regulation of appetite