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Energy expenditure The glucagon arm adds increased energy use the feature that distinguishes it from dual agonists

If discontinuation rates drop even modestly, the population-level weight-loss outcome can rival a more potent drug taken less consistently

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The time delay is due to the reduction of oxidative stress & pigment reduction internally

(54) found that administering GIPR antagonist to healthy humans reduced postprandial insulin secretion and increased glucose excursions more than administering GLP-1R antagonist (GLP-1RA), indicating that endogenous GIP may play a more significant role in stimulating insulin secretion and reducing postprandial plasma glucose excursions compared to endogenous GLP-1

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