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M., and Georgescu, E

In general, the most frequently reported symptoms in cirrhosis include: pain (prevalence range 3079%), breathlessness (2088%), muscle cramps (5668%), sleep disturbance (insomnia 2677%, daytime sleepiness 29.571%), psychological symptoms (depression 4.564%, anxiety 1445%), and erectile dysfunction (5393%) in men (3, 4)

10.1517/14728222.2012.680957 12 ChengZ.LiuL.ZhangX

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Individuals with genetic slow-metabolizer phenotypes, chronic liver disease, malnutrition, or concurrent enzyme-inhibiting medications should discuss lower thresholds with their provider before regular acetaminophen use

Thus, DNTB method grants measurement of free GSH, oxidized GSH (GSSG) and total content of GSH (free GSH + GSSG) in a multi-step approach in biological samples