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The molecule has two asymmetric carbons at the 3 and 3 positions on the -ionone rings, giving rise to three optical stereoisomers: (3S,3S), (3R,3R), and the meso form (3R,3S)

Chemistry of Materials 30 , 19471955, (2018)

The use of ferroptosis inhibitors can reduce hepatocyte death and inflammation during NAFLD and alleviate the progression of NAFLD

Its activity is regulated by various factors including oxidative stress levels, availability of NADPH (which links GR activity to glucose metabolism via the pentose phosphate pathway), and cellular energy status