Standards of Care in Diabetes-2024
In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (Hamilton and Holscher, 2009)
injections of 100 nmol kg 1 MK-801 ( n = 9 mice and 4 cages), 100 nmol kg 1 GLP-1 ( n = 10 mice and 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 10 mice and 4 cages), or vehicle (isotonic saline, n = 10 mice and 4 cages) for 14 days
Wegovy is titrated up to a higher maintenance dose of 2.4 mg of semaglutide weekly, which is optimized for weight loss
Mimicking the hormones slows digestion and makes patients feel full
(PubMed) Lee DM, Tajar A, Ulubaev A, et al