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Data extraction Two designated authors (AM and SS) meticulously extracted pertinent data from the included studies, including authorship details, publication timeline, samples of the study, mean demographic parameters (e.g., age, sex, baseline weight, and baseline BMI), type of bariatric surgery, prevalent background diseases, type of the GLP-1RAs therapy, the time of the initiation of the medical treatment, laboratory indices, amount of weight-change, and a comprehensive array of outcome measures, such as nausea, vomiting, diarrhea, and serious adverse events

The mechanism of action involves activation of both GIP and GLP-1 receptors, which are naturally occurring incretin hormones that play important roles in glucose homeostasis and appetite regulation

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Clinical trials demonstrate that semaglutide typically achieves around 15% weight loss and liraglutide 58% over 68 weeks, even with minimal physical activity

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