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Approved GLP-1 RAs in Canada include semaglutide, liraglutide, and dulaglutide

A 2012 prospective study of 278 postmenopausal women found that intentional weight loss of roughly 7.7 kg produced a 13.4% reduction in free estradiol and a 9.9% reduction in total estradiol, along with a 16.2% increase in SHBG

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The negative reviews center on billing issues, particularly unexpected charges after cancellation attempts, difficulty reaching customer service, and refund problems

Those peptides activate one or two receptors

But the FDA wants to make sure these GLP-1 versions are safe and effective