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These cells appear to contribute to the aging process and age-related diseases through the senescence-associated secretory phenotype (SASP), which fosters a pro-inflammatory environment detrimental to tissue function and integrity

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Prakash, Krishna et al (2022) Trncated Human IRF-1 (1-233) protein shows neutral transcriptional effect on expression of Bax, survivin, Bcl2 and cyclin D1 genes in HEK293T cell line

For those coming from semaglutide , the semaglutide to tirzepatide conversion guide provides approximate equivalence ratios, though individual responses vary significantly