The trials behind oral glutathione used 250mg to 500mg a day not multi-gram "mega doses." One study testing a large 3-gram single dose found it didn't meaningfully raise blood glutathione levels at all
However, these assays were difficult to interpret due to the high levels of spontaneous hydrolysis with the succinyl esters
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2011;7:539 Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ
Ethics declarations Competing interests The corresponding author Guang-ji Wang is a member of the Editorial Board of the journal Acta Pharmacologica Sinica, but he has not been involved in the peer-review or decision-making process for this manuscript
However, the role of L-carnitine on modulating high carbohydrate diet in fish is largely unknown