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A 7-fold increase in bioavailability means that a 500 mcg oral dose of the arginate form could deliver the equivalent systemic exposure of approximately 3,500 mcg of the acetate form taken orally

Slower dose escalationan approach PlexusDx emphasizesshortens the duration and severity of symptoms in most patients

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Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

To achieve a comparable therapeutic effect, patients must ingest a significantly higher daily dose, include absorption enhancers in the formulation, and take the medication while fasting