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The GLP-1R, as an integral membrane protein and 7-TMD GPCR, tightly interacts with its lipid-rich plasma membrane microenvironment (51) and is also known to segregate to cholesterol-rich flotillin-positive lipid nanodomains upon activation (25)

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LV, Left ventricular

One ml aliquot of the supernatant was neutralized with 1.5 ml of 0.5 M phosphate buffers (pH 7.5), then 50 l H 2 O was added

In the matched cohort, which controlled for potential confounding factors, GLP-1 use was associated with a 30.5% reduction in breast cancer incidence