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Reduced likelihood of weight regain with medical support

Hepatocyte-specific deletion of SIRT1 results in hepatic inflammation and steatosis (Purushotham et al

The 2mg dose primarily activates GLP-1 with minimal glucagon receptor engagement

This means they cannot model the blood-brain barrier, develop necrotic cores during long-term culture, and cannot replicate how peripheral immune cells travel into the brain a central feature of TBM pathology