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Headaches and dizziness during the initial days often reflect dehydration or rapid blood sugar changes rather than direct drug toxicity

Data are lacking from long-term studies to assess whether oral treatment is effective when doses are administered less frequently than daily

doi: 10.1152/ajprenal.1982.242.5.F484

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Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease and cancer: US Preventive Services Task Force recommendation statement