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Johnson TM, Yu ZX, Ferrans VJ, Lowenstein T, Finkel T: Reactive oxygen species are downstream mediators of p53 dependent apotposis

FDA adverse event data (as of early 2025) 455+ adverse event reports linked to compounded semaglutide 320+ adverse event reports linked to compounded tirzepatide Many involved dosing errors from multidose vials, some requiring hospitalization Reports include severe nausea, vomiting, dehydration, and overdose symptoms Documented contamination, mislabeling, and counterfeit product cases 1