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Longer uninterrupted dosing is not recommended because receptor sensitivity can diminish without cycling

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Moreover, in the lung, non-neuronal cells, known as neuroendocrine cells, synthesize and secrete neuropeptides

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Normal mucus formation requires cAMP-dependent HCO3 secretion and Ca2+-mediated mucin exocytosis

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Annals of the New York Academy of Sciences, 1270, 6672

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The additional benefits of higher doses come primarily from the other two receptors, not from more GLP-1 activity

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