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Individual variability in response is high, with no way to predict who will benefit

Finally, combining vectors with biocompatible scaffolds or hydrogels may extend intra-articular retention and promote localized expression

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Mechanistically, taxifolin suppressed LPS-induced activation of the NF-B pathway, as indicated by decreased phosphorylation of NF-B, along with reduced MLCK expression and MLC phosphorylation

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