Results announced in December 2025 confirmed the Phase 2 findings at a longer timepoint (Lilly Press Release, Dec 2025): The 28.7% weight loss at 68 weeks exceeds both semaglutide (~15% in STEP trials) and tirzepatide (~22.5% in SURMOUNT trials) at similar timepoints
In the STEP-2 study 36 , semaglutide 2.4 mg showed a 6.0% incidence of psychiatric events compared to 3.7% in the placebo group
The Institute for Clinical and Economic Review (ICER) found that the lifetime employer cost for Wegovy would be $274,400 , while the medical costs averted over a lifetime would be $61,600
In other words, Zepbound helps you feel full for a longer amount of time, which prevents you from consuming more calories throughout the day
What is the future outlook for oral GLP-1 medications
Could reduced food intake place me at risk for a nutritional deficiency