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All use must comply with applicable EU regulations, including Regulation (EC) No 1907/2006 (REACH), national laws of the purchaser's country, and all applicable institutional policies

Self-monitoring strategies include keeping a symptom diary, tracking mood and appetite changes, recording weight weekly rather than daily (to avoid obsessive behaviors), and noting any new or worsening side effects

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Instead, it leverages the UKPDS82 dataset [29], which inherently incorporates the combined effects of these risk factors as observed longitudinally in a well-characterized cohort, within this analytical framework, HbA1c reductions observed in the SUSTAIN 7 trial [22] function as a primary, though not exclusive, determinant of microvascular risk, and as one of several contributors to macrovascular risk, against the background of the integrated risk profile emulated by the UKPDS structure

All patients initially entered an 8-week insulin dose-titration phase