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Although the overall disease progression of NAFLD has been characterized, the exact mechanism(s) underlying its initiation and progression remain poorly defined

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The ACCORD trial ended its intensive therapy early, after 3.5 years, because of a significant increase in deaths in the intensive-therapy group

2021 Jul 30;14:3651-3664

Its stability window narrows significantly

(2016) found that acute fluoxetine administration in prepubertal female rats resulted in increased estradiol concentrations, whereas subchronic administration led to increased serotonin concentrations in the ovaries, a decrease in the number of ovulations, a greater number of atretic follicles, and oocyte fragmentation