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After 72 weeks: Participants taking 6 mg of orforglipron lost an average of 7.5% of their body weight (equivalent to 9 mg of Foundayo) Participants taking 12 mg or 37 mg of orforglipron lost an average of 8.4% and 11.2%, respectively (equivalent to 14.5 mg or 17.2 mg of Foundayo, respectively) Side effects and risks of GLP-1s The most common side effects from these medicines are mild gastrointestinal (GI) issues, such as: Vomiting Diarrhea Abdominal pain Rare but serious side effects of GLP-1s may include: Pancreatitis, or inflammation of the pancreas Gallbladder disease (including gallstones or gallbladder inflammation) Low blood sugar ( hypoglycemia ), particularly in people who also take insulin or certain pills for diabetes Severe allergic reactions Severe gastrointestinal reactions, which may lead to dehydration and related kidney problems Diabetic retinopathy complications in people with this eye disease Risk of pulmonary aspiration ( stomach contents entering the lungs) during surgery in people undergoing deep sedation or anesthesia GLP-1s also carry a boxed warning because they caused thyroid C-cell tumors in studies of rats

The dose-response curve explained At the 1mg level, participants lost 8.7% of body weight over 48 weeks

Regulatory Guidelines and Mitigation Strategies for the Immunogenicity of Peptide-Oligonucleotide Conjugates Regulatory expectations established by the FDA and EMA require a phase-appropriate, risk-based strategy for mitigating immunogenicity that integrates molecular de-immunization, chemical modification of the oligonucleotide backbone, and stringent control of critical quality attributes (CQAs)

1997 Nov-Dec Cristiana Paul, David M Brady

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DSIP did not produce a significant effect on the measured ACTH or cortisol responses