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Furthermore, as changes occur at varying levels and in different pathways that result in enhancement of neurogenesis, synaptic plasticity, brain structure, and function, CR has also been shown to be beneficial for cognitive protection and improvement of slowing down the progression of cognitive age-related diseases such as Alzheimers disease (Van Cauwenberghe et al., 2016

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As a proxy for heavy smoking (binary variable), we used diagnosis codes related to lung diseases highly associated with tobacco exposure along with diagnosis codes related to nicotine or tobacco, previous use of medications for the treatment of tobacco dependence, and initiation of drugs for obstructive airway disease after the age of 40

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I saw my percent body fat go down and my lean muscle increase, which are actually way better markers and metrics of well-being and longevity than a BMI, which often kind of gets it wrong, he says