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Notably, activation of Akt signaling during exercise leads to the phosphorylation of Akt substrate of 160kDa (AS160), a Rab GTPase-activating protein

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The antidiabetic drug repaglinide enhanced PINK1 expression, significantly inhibited cell apoptosis, and alleviated neuroinflammation and PD symptoms by activating mitophagy in a PD model [192]

It also enhances skin elasticity and firmness, contributing to a youthful appearance

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2010;341:c4229