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Disruption of the gut barrier, adipose tissue inflammation, and hepatic immune activity are interconnected and collectively drive disease progression

In line with this observation, 2-hydroxybutyrate is increasingly recognized as a biomarker of metabolic disturbances, particularly in insulin resistance and glucose intolerance 27

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doi: 10.1016/j.celrep.2021.108929 27 MarstonALWassmannK

The decrease is directly proportional to the GPx activity in the sample