More recently, a long-acting exendin-4-based analog bound to the Fc portion of immunoglobulin G (IgG) known as efpeglenatide is under clinical development, and would also be suitable for a once-weekly injection [8,9]
In addition to liver health, GLP-1 receptor agonists have demonstrated cardiovascular benefits, and potential neuroprotective properties, and may even play a role in lowering the risks of certain cancers
Both neurogenic inflammation and oxidative stress are key factors in migraine development, and topiramates neuroprotective potential through its anti-inflammatory and antioxidative effects is noted
While the marketing authorisation covers BMI 30 kg/m or 27 kg/m with weight-related comorbidities, NHS prescribing follows NICE Technology Appraisal criteria, which are more restrictive
GLP-1 Receptor Agonists and Cardiorenal Outcomes in Type 2 Diabetes: An Updated Meta-Analysis of Eight CVOTs
If the pen has been frozen, exposed to temperatures above 86F for any period, or left at room temperature beyond 21 days while unopened, it must be discarded regardless of appearance
