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Guinea pigs (Hartley, both sexes, 500-700 g b.w.) with whole body plethysmography, urethane anesthesia (1.5 g/kg i.p.), artificial ventilation under constant pressure (0.98 kPa), and relaxation of skeleton musculature by suxamethonium (0.2 mg/kg i.v.) were used in the present experiments

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Preclinical data from the University of Arizona showed maximal receptor occupancy at 10^-9 M concentrations in cortical neuron cultures, with no additional signaling observed when concentrations increased tenfold

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These effects are likely due to its multifunctional biological activity, which includes reducing corticosterone levels and promoting adaptation to stress 4