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Several oxysterols including 24S-OHC, 25-OHC, 27-OHC, 7-KC can activate Mitogen-Activated Protein Kinase (MAPK) signaling pathways (Extracellular Signal-Regulated Kinase - ERK1/2, JNK, and p38) through the generation of ROS, which engage redox-sensitive kinases upstream of MAPK

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